Side‐to‐side supercharging nerve allograft enhances neurotrophic potential
نویسندگان
چکیده
منابع مشابه
A glial cell line-derived neurotrophic factor delivery system enhances nerve regeneration across acellular nerve allografts.
UNLABELLED Acellular nerve allografts (ANAs) are used clinically to bridge nerve gaps but these grafts, lacking Schwann cells and therapeutic levels of neurotrophic factors, do not support regeneration to the same extent as autografts. Here we investigated a local drug delivery system (DDS) for glial cell line-derived neurotrophic factor (GDNF) controlled release to implanted ANAs in rats using...
متن کاملStimulating the neurotrophic and angiogenic properties of human adipose-derived stem cells enhances nerve repair.
In future, adipose-derived stem cells (ASC) might be used to treat neurological disorders. In this study, the neurotrophic and angiogenic properties of human ASC were evaluated, and their effects in a peripheral nerve injury model were determined. In vitro growth factor stimulation of the cells resulted in increased secretion of brain-derived neurotrophic factor (BDNF), glial cell-derived neuro...
متن کاملPeripheral nerve regeneration and neurotrophic factors.
The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells has been the subject of numerous studies. Administration of exogenous neurotrophic factors after nerve injury has been shown to mimic the effect of target organ-derived trophic factors on neuronal cells. After axotomy and during peripheral nerve regeneration, the neurotrophins NGF, NT-3 and BDNF show a...
متن کاملNeurotrophic factors and corneal nerve regeneration
The cornea has unique features that make it a useful model for regenerative medicine studies. It is an avascular, transparent, densely innervated tissue and any pathological changes can be easily detected by slit lamp examination. Corneal sensitivity is provided by the ophthalmic branch of the trigeminal nerve that elicits protective reflexes such as blinking and tearing and exerts trophic supp...
متن کاملAllograft reconstruction for digital nerve loss.
PURPOSE To investigate the outcomes of digital nerve repairs using processed nerve allograft for defects measuring 30 mm or less. METHODS Seventeen patients with 21 digital nerve lacerations in the hand underwent reconstruction with processed nerve allograft. Outcome data for 14 patients with 18 digital nerve lacerations were available for analysis. Postoperative outcome data were recorded at...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Muscle & Nerve
سال: 2019
ISSN: 0148-639X,1097-4598
DOI: 10.1002/mus.26753